About Metoclopramide HCl (MOTILLEX) 5mg/5mL Syrup 60mL

Metoclopramide HCl (MOTILLEX) 5mg/5mL Syrup 60mL is an oral gastrointestinal stimulant and antiemetic designed to relieve symptoms of nausea, vomiting, and delayed gastric emptying, especially in pediatric and adult patients who require or prefer liquid medication. Each 5 mL of syrup contains 5 mg of metoclopramide hydrochloride, an active compound that enhances gastric motility and accelerates gastric emptying without increasing gastric secretions.

This syrup formulation is especially suited for children or patients who have difficulty swallowing tablets. It offers convenient and accurate dosing with a pleasant taste, making it ideal for home or clinical use. Metoclopramide works primarily by blocking dopamine receptors in the brain and gastrointestinal tract, reducing the signals that trigger nausea and vomiting, while promoting coordinated contractions of the upper digestive tract.

MOTILLEX Syrup is widely used in the treatment of gastroesophageal reflux disease (GERD), diabetic gastroparesis, postoperative nausea and vomiting, and to support feeding in patients with difficulty emptying the stomach. It is often prescribed for short-term use and should be used under medical supervision due to the potential for neurological side effects, particularly with prolonged administration.

Indications of Metoclopramide HCl (MOTILLEX) 5mg/5mL Syrup 60mL

• Nausea and vomiting: Prevention and treatment due to chemotherapy, infections, or gastrointestinal disorders. 
• GERD (gastroesophageal reflux disease): Especially in patients unresponsive to antacids and acid-suppressing therapy. 
• Diabetic gastroparesis: To relieve symptoms such as bloating, early satiety, and nausea. 
• Facilitation of feeding tube placement or radiologic examination requiring gastric emptying. 
• Postoperative nausea and vomiting. 

Dosage and Administration of Metoclopramide HCl (MOTILLEX) 5mg/5mL Syrup 60mL

• Adults: 
  • 10 mg (10 mL) taken orally up to three times daily before meals and at bedtime. 
  • Maximum treatment duration: 5 days unless otherwise advised by a physician. 
• Children (1–14 years old): 
  • 0.1 to 0.15 mg/kg body weight per dose, given 3 times daily. 
  • Do not exceed 0.5 mg/kg/day. 
  • Dosing should be strictly supervised by a healthcare provider. 
• Important Notes: 
  • Always administer before meals. 
  • Use calibrated dosing cups or syringes for accuracy. 
  • Do not exceed prescribed duration to avoid risk of extrapyramidal symptoms. 

Contraindications of Metoclopramide HCl (MOTILLEX) 5mg/5mL Syrup 60mL

• Known hypersensitivity to metoclopramide or any component of the syrup. 
• History of tardive dyskinesia or extrapyramidal reactions. 
• Epilepsy or seizure disorders. 
• Gastrointestinal obstruction, hemorrhage, or perforation. 
• Parkinson’s disease. 
• Pheochromocytoma (risk of hypertensive episodes). 
• In children under 1 year of age (increased risk of neurologic side effects). 

Side Effects

Common:

• Drowsiness or fatigue 
• Restlessness 
• Diarrhea 

Serious (rare):

• Extrapyramidal symptoms (involuntary muscle movements) 
• Tardive dyskinesia (especially with long-term use) 
• Depression or suicidal thoughts 
• Neuroleptic malignant syndrome 

Precautions

• Use with caution in elderly patients and those with kidney or liver impairment. 
• Avoid combining with other dopamine antagonists or serotonergic drugs without supervision. 
• Limit use to the shortest duration possible to avoid neurologic complications. 

Storage Instructions

• Store at temperatures not exceeding 30°C. 
• Keep the bottle tightly closed and out of reach of children. 
• Shake well before use.