About Metoclopramide (METOCLOSIL) 5mg/mL 2mL Ampoule 10’s

Metoclopramide (METOCLOSIL) 5mg/mL 2mL Ampoule 10’s is a fast-acting injectable antiemetic and gastroprokinetic agent commonly used in clinical and emergency settings. Each ampoule contains 5 mg of metoclopramide per milliliter, delivering a total of 10 mg per 2 mL dose. This sterile solution is designed for intramuscular (IM) or slow intravenous (IV) administration, offering rapid relief of nausea, vomiting, and gastric stasis symptoms.

Metoclopramide works by antagonizing dopamine D2 receptors in the chemoreceptor trigger zone (CTZ) of the brain and enhancing gastrointestinal motility without stimulating gastric, biliary, or pancreatic secretions. It accelerates gastric emptying and improves esophageal sphincter tone, making it beneficial in managing delayed gastric emptying, gastroesophageal reflux disease (GERD), and post-operative nausea.

Healthcare professionals utilize METOCLOSIL as part of supportive care for patients undergoing chemotherapy, radiation therapy, or surgical procedures. The injectable form is particularly advantageous when oral administration is not feasible due to vomiting or impaired gastric function.

Indications of Metoclopramide (METOCLOSIL) 5mg/mL 2mL Ampoule 10’s

• Prevention and treatment of nausea and vomiting: Including those caused by chemotherapy, radiotherapy, surgery, or migraines. 
• Gastroparesis (delayed gastric emptying): Especially in diabetic patients. 
• GERD (gastroesophageal reflux disease): As an adjunct to standard acid-suppressing therapy. 
• Facilitation of small bowel intubation: In radiological procedures. 
• Preoperative use: To reduce the risk of aspiration by promoting gastric emptying. 

Dosage and Administration of Metoclopramide (METOCLOSIL) 5mg/mL 2mL Ampoule 10’s

• Adults: 
  • Typical dose: 10 mg (2 mL) via IM or slow IV injection up to three times daily. 
  • IV injection should be administered over at least 1–2 minutes. 
  • For chemotherapy-induced nausea, dosing may vary based on regimen and weight. 
• Children (under medical supervision): 
  • Dosage is based on body weight (0.1–0.15 mg/kg/dose). 
  • Should not exceed 0.5 mg/kg/day. 
• Important notes: 
  • Treatment duration should typically not exceed 5 days. 
  • Always assess renal function for dose adjustments in patients with impairment. 

Contraindications of Metoclopramide (METOCLOSIL) 5mg/mL 2mL Ampoule 10’s

• Hypersensitivity to metoclopramide or any component of the formulation. 
• History of tardive dyskinesia or drug-induced movement disorders. 
• Gastrointestinal bleeding, obstruction, or perforation. 
• Pheochromocytoma (risk of hypertensive crisis). 
• Epilepsy or other seizure disorders. 
• Parkinson’s disease (may worsen symptoms). 

Side Effects of Metoclopramide (METOCLOSIL) 5mg/mL 2mL Ampoule 10’s

Common:

• Drowsiness 
• Fatigue 
• Restlessness 

Less common but serious:

• Extrapyramidal symptoms (involuntary movements, especially in children and young adults) 
• Tardive dyskinesia (in long-term use) 
• Neuroleptic malignant syndrome 
• Depression or suicidal thoughts (rare) 

Precautions

• Use with caution in the elderly or those with kidney dysfunction. 
• Avoid concurrent use with other dopamine antagonists or serotonergic drugs unless supervised. 
• Not recommended for long-term use due to the risk of neurological side effects. 

Storage Instructions

• Store below 25°C, protected from light. 
• Do not freeze. 
• Use immediately after opening an ampoule; discard any unused portion.