About Rifampicin + Isoniazid + Pyrazinamide + Ethambutol HCl (QUADMAX) Tablet 80’s

Rifampicin + Isoniazid + Pyrazinamide + Ethambutol HCl (QUADMAX) Tablet 80’s is a powerful combination therapy indicated for the treatment of active tuberculosis (TB). This formulation integrates four essential first-line anti-TB drugs—rifampicin, isoniazid, pyrazinamide, and ethambutol hydrochloride—into a single tablet to enhance patient compliance and streamline treatment protocols.

Rifampicin is a bactericidal antibiotic that inhibits bacterial RNA synthesis. Isoniazid interferes with the synthesis of mycolic acids essential to the mycobacterial cell wall. Pyrazinamide is particularly active against semi-dormant bacteria in acidic environments, while ethambutol disrupts cell wall formation by inhibiting arabinosyl transferases.

This fixed-dose combination is particularly useful during the intensive phase of TB treatment, ensuring the delivery of the appropriate drug ratios to minimize resistance and improve outcomes.

Indications of Rifampicin + Isoniazid + Pyrazinamide + Ethambutol HCl (QUADMAX) Tablet 80’s

Rifampicin + Isoniazid + Pyrazinamide + Ethambutol HCl (QUADMAX) Tablet 80’s is indicated for:

• The initial intensive phase treatment of active pulmonary and extrapulmonary tuberculosis

• Use as part of a directly observed treatment, short-course (DOTS) strategy endorsed by WHO

• Treatment of drug-sensitive TB strains in combination with continuation-phase therapy

Dosage and Administration of Rifampicin + Isoniazid + Pyrazinamide + Ethambutol HCl (QUADMAX) Tablet 80’s

The dosage depends on the patient’s body weight and must be determined by a healthcare provider. Commonly used dosing schedule (daily regimen):

• Weight 30–37 kg: 2 tablets once daily

• Weight 38–54 kg: 3 tablets once daily

• Weight 55–70 kg: 4 tablets once daily

• Weight >70 kg: 5 tablets once daily

Tablets should be taken on an empty stomach at least 1 hour before or 2 hours after meals to ensure optimal absorption.

Side Effects of Rifampicin + Isoniazid + Pyrazinamide + Ethambutol HCl (QUADMAX) Tablet 80’s

Common side effects include:

• Gastrointestinal upset (nausea, vomiting, abdominal pain)

• Reddish-orange discoloration of body fluids (due to rifampicin)

• Fatigue, joint pains

• Increased liver enzymes or hepatotoxicity

• Visual disturbances (due to ethambutol)

Rare but serious side effects:

• Peripheral neuropathy (due to isoniazid)

• Hepatitis or liver failure

• Hypersensitivity reactions (rash, fever)

• Optic neuritis (especially with prolonged ethambutol use)

Contraindications of Rifampicin + Isoniazid + Pyrazinamide + Ethambutol HCl (QUADMAX) Tablet 80’s

Rifampicin + Isoniazid + Pyrazinamide + Ethambutol HCl (QUADMAX) Tablet 80’s is contraindicated in:

• Patients with known hypersensitivity to any of the four components

• Individuals with severe hepatic impairment or active liver disease

• Patients with optic neuritis or known visual disturbances (due to ethambutol)

• History of drug-induced hepatitis or severe adverse reaction to anti-TB drugs

Precautions for Rifampicin + Isoniazid + Pyrazinamide + Ethambutol HCl (QUADMAX) Tablet 80’s

• Monitor liver function tests regularly during therapy

• Use with caution in patients with renal impairment, diabetes, or alcoholism

• Pyridoxine (vitamin B6) supplementation is often recommended to reduce the risk of peripheral neuropathy

• Patients should be advised about possible discoloration of urine, saliva, and tears

Storage of Rifampicin + Isoniazid + Pyrazinamide + Ethambutol HCl (QUADMAX) Tablet 80’s

• Store in a cool, dry place below 30°C

• Protect from moisture and direct sunlight

• Keep out of reach of children