About Gliclazide (GLIFRED MR) 60mg Tablet 30’s

Gliclazide (GLIFRED MR) 60mg Tablet 30’s is a modified-release oral antidiabetic medicine designed to control blood glucose levels in adults with type 2 diabetes mellitus. As a second-generation sulfonylurea, Gliclazide works by stimulating insulin secretion from pancreatic beta cells, thereby lowering blood sugar levels. The modified-release (MR) form provides a gradual and sustained release of the drug over time, allowing for once-daily dosing and steady glycemic control throughout the day. It is typically prescribed in combination with diet and exercise and may also be used with other antidiabetic medications when monotherapy is inadequate. Gliclazide not only helps reduce blood glucose levels but also contributes to improved insulin sensitivity and may have protective effects on blood vessels.

Indications of Gliclazide (GLIFRED MR) 60mg Tablet 30’s

• Indicated for the management of type 2 diabetes mellitus in adults.

• Used when diet, physical activity, and weight reduction alone do not achieve sufficient blood glucose control.

• Can be used alone or in combination with other antidiabetic agents such as metformin, thiazolidinediones, or insulin.

• Aims to prevent long-term complications of diabetes by maintaining target glycemic levels.

Dosage of Gliclazide (GLIFRED MR) 60mg Tablet 30’s

• The usual starting dose is 30–60 mg once daily, taken with breakfast.

• Dosage may be adjusted based on the patient’s blood glucose response, up to a maximum of 120 mg daily.

• Tablets should be swallowed whole and not crushed or chewed, to maintain the modified-release properties.

• Blood glucose and HbA1c levels should be monitored regularly to ensure effectiveness and avoid hypoglycemia.

Side Effects of Gliclazide (GLIFRED MR) 60mg Tablet 30’s

Common side effects:

• Hypoglycemia (especially if meals are missed or delayed)

• Dizziness or headache

• Gastrointestinal discomfort (nausea, abdominal pain)

• Weight gain

Less common or rare side effects:

• Skin rashes or allergic reactions

• Elevated liver enzymes or liver dysfunction

• Changes in vision (usually temporary)

• Hematological changes such as anemia, leukopenia, or thrombocytopenia (rare)

Patients should be educated about the signs of low blood sugar and advised to carry sugar sources (e.g., glucose tablets) when using this medication.

Precautions for Gliclazide (GLIFRED MR) 60mg Tablet 30’s

• Not intended for type 1 diabetes or diabetic ketoacidosis.

• Caution is required in elderly patients and those with renal or hepatic impairment.

• Alcohol may enhance the hypoglycemic effect and should be limited.

• Regular monitoring of blood glucose levels, especially during dose adjustments or when used with other antidiabetic drugs.

• Inform your doctor if you are planning for surgery, pregnancy, or are breastfeeding.

• Avoid skipping meals to reduce the risk of hypoglycemia.

Contraindications of Gliclazide (GLIFRED MR) 60mg Tablet 30’s

• Known hypersensitivity to Gliclazide, other sulfonylureas, or sulfonamide derivatives

• Type 1 diabetes mellitus

• Diabetic ketoacidosis or diabetic pre-coma

• Severe renal or hepatic insufficiency

• Pregnancy and lactation

• Concurrent use of miconazole (increased risk of severe hypoglycemia)

• Patients with a history of porphyria or acute metabolic disorders

Storage of Gliclazide (GLIFRED MR) 60mg Tablet 30’s

Store in a cool, dry place at a temperature not exceeding 30°C. Keep away from moisture, heat, and direct sunlight. Store in the original packaging to protect from light.
Keep out of reach of children and pets. Do not use the product past its expiry date.