About Rifampicin + Isoniazid (DUOMAX) 150mcg/75mg Tablet
Rifampicin + Isoniazid (DUOMAX) 150mcg/75mg Tablet is indicated for the treatment and prevention of:
- Active tuberculosis (in combination with other anti-TB drugs)
- Latent tuberculosis (to prevent progression to active TB)
Dosage:
Anti-tuberculosis short course chemotherapy recommended by World Health Organization (WHO) involves an intensive phase followed by a continuation phase for 4 months (Fixcom 2); involves an initial phase and a continuation phase (Fixcom 3); involves an initial using a combination of drugs to produce rapid killing of the tubercle bacilli (Fixcom 4).
The tablets should be taken one hour before or two hours after meals.
Fixcom 2: The dosage schedule will follow the recommended WHO TB treatment regimens. The number of tablets of fixed-dose combination tablets per patient will depend on the body weight. Hence, all patients must be weighed (using kilogram as a unit) before treatment is started.
Patients <55 kg: 3 tabs/day.
Patients 55-70 kg: 4 tabs/day.
Patients >70 kg: 5 tabs/day.
Fixcom 3: The continuation phase of 4-6 months using combination drugs with the aim of elimination of any remaining organisms and thus preventing recurrence.
Fixcom 4: For the initial phase: Fixcom 4 is given for 2 months.
Ethambutol should be given in reduced dosage to patients with impaired kidney function and dosage adjustments may need to be made according to serum concentrations.
Overdosage of Rifampicin + Isoniazid (DUOMAX) 150mcg/75mg Tablet:
Isoniazid: Symptoms of overdosage include slurred speech, metabolic acidosis, hyperglycemia, convulsions and coma; fatalities may occur.
Ethambutol: Blood concentrations of ethambutol following overdosage may be reduced by hemodialysis or peritoneal dialysis.
Administration of Rifampicin + Isoniazid (DUOMAX) 150mcg/75mg Tablet:
Should be taken on an empty stomach: Take 1 hr before or 2 hr after meals.
Contraindications of Rifampicin + Isoniazid (DUOMAX) 150mcg/75mg Tablet:
Ethambutol: Ethambutol is generally contraindicated in patients with optic neuritis. It should be generally not be used in children <6 years and some consider that it should not be used in children <13 years nor in patients with visual defects.
Fixcom 4: Pyrazinamide: Patients with liver damage, although some consider that it can be used with care when the liver damage is not severe.
Pyrazinamide should not be given to patients with acute gout or hyperuricemia.
Storage Instructions:
Store Rifampicin + Isoniazid (DUOMAX) 150mcg/75mg Tablet 80’s in a cool, dry place at a temperature not exceeding 30°C (86°F). Keep the tablets in their original packaging and protect them from direct sunlight, heat, and moisture. Ensure the medication is stored out of reach of children.
















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