About Metformin (GLYCEMET) 500mg Tablet 100’s

Metformin (GLYCEMET) 500mg Tablet 100’s is an oral antidiabetic medication belonging to the biguanide class, used primarily for the management of type 2 diabetes mellitus. It helps control blood sugar levels by reducing hepatic glucose production, decreasing intestinal absorption of glucose, and improving insulin sensitivity in peripheral tissues. As a first-line therapy for type 2 diabetes, Metformin is highly effective and widely prescribed, especially in overweight or obese patients, as it does not typically cause weight gain and has a low risk of hypoglycemia when used alone.

GLYCEMET 500mg tablets are formulated for consistent blood glucose control and are typically taken once or twice daily with meals to minimize gastrointestinal side effects. Metformin is also used in combination with other antidiabetic agents, including sulfonylureas, DPP-4 inhibitors, or insulin, for improved glycemic control when monotherapy is not sufficient.

Beyond diabetes, Metformin is also used off-label in conditions like polycystic ovary syndrome (PCOS) to improve insulin resistance and ovulatory function.

Indications of Metformin (GLYCEMET) 500mg Tablet 100’s

• Type 2 diabetes mellitus (non-insulin-dependent diabetes) as monotherapy or in combination with other antidiabetic medications
• Polycystic ovary syndrome (PCOS) – off-label use
• Prevention of type 2 diabetes in high-risk individuals (impaired glucose tolerance) – under clinical guidance

Dosage and Administration of Metformin (GLYCEMET) 500mg Tablet 100’s

• Initial dose: 500 mg once or twice daily with meals
• Maintenance dose: Gradually increased to 1500–2000 mg per day in divided doses
• Maximum dose: 2550 mg per day
• Tablets should be taken with meals to reduce gastrointestinal discomfort

Contraindications of Metformin (GLYCEMET) 500mg Tablet 100’s

• Hypersensitivity to Metformin or any component of the formulation
• Renal impairment (eGFR <30 mL/min/1.73 m²)
• Acute or chronic metabolic acidosis, including diabetic ketoacidosis
• Severe hepatic dysfunction
• Conditions associated with hypoxia (e.g., heart failure, respiratory failure)
• Recent history of myocardial infarction or septicemia
• Alcohol abuse (due to increased risk of lactic acidosis)

Side Effects of Metformin (GLYCEMET) 500mg Tablet 100’s

Common side effects:

• Nausea
• Diarrhea
• Abdominal discomfort
• Metallic taste
• Loss of appetite

Serious but rare side effects:

• Lactic acidosis (a rare but potentially fatal condition)
• Vitamin B12 deficiency with long-term use

Precautions for Metformin (GLYCEMET) 500mg Tablet 100’s

• Monitor kidney function regularly, especially in elderly patients
• Avoid excessive alcohol intake
• Discontinue temporarily before any procedure involving iodinated contrast agents
• Use with caution in patients with liver impairment or heart failure
• Consider vitamin B12 level monitoring with prolonged therapy

Storage Instructions for Metformin (GLYCEMET) 500mg Tablet 100’s

• Store at temperatures not exceeding 30°C
• Keep in a dry place away from light and moisture
• Keep out of reach of children