Losartan + Amlodipine (AMLORA) 50mg/5mg Tablet 30’s

About Losartan + Amlodipine (AMLORA) 50mg/5mg Tablet

Losartan + Amlodipine (AMLORA) 50mg/5mg Tablet is a combination medication that combines two active ingredients: Amlodipine (a calcium channel blocker) and Losartan Potassium (an angiotensin II receptor blocker, or ARB). This combination is used primarily to treat high blood pressure (hypertension) and to improve cardiovascular outcomes. The tablet contains 5mg of Amlodipine and 50mg of Losartan, which work together to help relax blood vessels, reduce blood pressure, and improve blood flow, thereby decreasing the workload on the heart.

Indications for Losartan + Amlodipine (AMLORA) 50mg/5mg Tablet :

Losartan + Amlodipine (AMLORA) 50mg/5mg Tablet is indicated for the following conditions:

• Hypertension (High Blood Pressure):
  • AMLORA is used to treat essential hypertension (high blood pressure) in adults when a combination of Amlodipine and Losartan is needed to effectively control blood pressure.
  • It can also be used in patients who require additional blood pressure control when Amlodipine and Losartan alone are not sufficient.
• Chronic Kidney Disease (in patients with hypertension and type 2 diabetes):
  • AMLORA is used in patients with hypertension and chronic kidney disease (especially those with type 2 diabetes) to reduce the progression of kidney damage.
  • Losartan helps reduce proteinuria (the presence of excess protein in the urine), which is often a sign of kidney damage.
• Reduction of the Risk of Stroke and Heart Failure:
  • In patients with left ventricular hypertrophy (enlarged heart) following a stroke, AMLORA may help in the prevention of stroke by reducing blood pressure and improving heart function.

Dosage Losartan + Amlodipine (AMLORA) 50mg/5mg Tablet :

The dosing of Losartan + Amlodipine (AMLORA) 50mg/5mg Tablet will depend on the patient’s individual needs and blood pressure response. Here are typical dosing guidelines:

• Initial Dose:
  • 1 tablet daily, containing 5mg of Amlodipine and 50mg of Losartan.
• Maintenance Dose:
  • The dose may be increased based on the individual patient’s response to treatment. The maximum recommended dose is 1 tablet daily containing 10mg of Amlodipine and 100mg of Losartan.
  • Dosage adjustments may be made after several weeks of treatment to achieve optimal blood pressure control.
• Special Populations:
  • For patients with kidney disease or mild-to-moderate liver impairment, AMLORA should be used with caution. Lower doses may be considered, and kidney function should be monitored regularly.
• Elderly:
  • Elderly patients may be more sensitive to the blood pressure-lowering effects of AMLORA, and it may be advisable to start at a lower dose (5mg/50mg) and monitor the patient carefully.

Side Effects of Losartan + Amlodipine (AMLORA) 50mg/5mg Tablet :

Like all medications, Losartan + Amlodipine (AMLORA) 100mg/5mg Tablet may cause side effects, although not everyone experiences them. Common and serious side effects include:

Common Side Effects:

• Dizziness or lightheadedness, particularly when standing up quickly (orthostatic hypotension).
• Swelling (edema) of the ankles, feet, or legs (more commonly with Amlodipine).
• Headache.
• Fatigue or tiredness.
• Flushing or feeling warm.
• Nausea or stomach discomfort.
• Cough (more likely with Losartan in rare cases).

Serious Side Effects:

• Severe allergic reactions: Symptoms include rash, swelling of the face, difficulty breathing, or tightness in the chest.
• Severe dizziness, fainting, or confusion: May indicate low blood pressure.
• High potassium levels (hyperkalemia): Symptoms may include muscle weakness, fatigue, or irregular heartbeat.
• Liver problems: Symptoms of liver dysfunction include yellowing of the skin or eyes (jaundice), dark urine, or persistent abdominal pain.
• Kidney dysfunction: Symptoms may include changes in urine output, swelling, or fatigue.
• Angioedema (swelling of the deeper layers of the skin): This can be a serious side effect, particularly with Losartan. If swelling of the lips, face, or throat occurs, immediate medical attention should be sought.
• Fainting or bradycardia (slow heart rate).

If any of these serious side effects occur, immediate medical attention should be sought.

Contraindications Losartan + Amlodipine (AMLORA) 50mg/5mg Tablet :

Losartan + Amlodipine (AMLORA) 50mg/5mg Tablet is contraindicated in the following conditions:

• Hypersensitivity to Amlodipine, Losartan, or any of the components of the tablet: If you are allergic to Amlodipine, Losartan, or any of the other ingredients in this medication, you should not take it.
• Severe hypotension (low blood pressure): AMLORA should not be used in patients with significantly low blood pressure.
• Severe hepatic impairment: AMLORA is contraindicated in patients with severe liver disease.
• Bilateral renal artery stenosis (narrowing of both kidneys’ arteries): Using AMLORA may further impair kidney function in these patients.
• Pregnancy (Category D): AMLORA is contraindicated during pregnancy because it can harm the unborn baby, particularly during the second and third trimesters. If pregnancy is detected, treatment should be discontinued immediately.
• Breastfeeding: AMLORA should be avoided during breastfeeding as it may pass into breast milk and affect the baby.
• Angioedema: Patients with a history of angioedema related to previous ACE inhibitors or ARBs (like Losartan) should not take this medication.

Precautions Losartan + Amlodipine (AMLORA) 50mg/5mg Tablet :

• Caution in patients with kidney disease: For patients with mild to moderate kidney impairment, the dose of AMLORA may need to be adjusted. Kidney function should be monitored regularly.
• Caution in patients with liver disease: Liver function should be checked regularly in patients with mild liver impairment. For severe liver disease, AMLORA is contraindicated.
• Caution in elderly patients: Elderly patients may be more sensitive to the effects of AMLORA, especially regarding blood pressure reduction and the risk of orthostatic hypotension. It is important to monitor blood pressure regularly in elderly patients.
• Potassium monitoring: Patients taking AMLORA should have their serum potassium levels monitored, as Losartan may increase the risk of hyperkalemia.
• Pregnancy and breastfeeding: AMLORA should not be used during pregnancy or breastfeeding. Alternative medications should be considered.

Drug Interactions:

Losartan + Amlodipine (AMLORA) 50mg/5mg Tablet can interact with several medications, including:

• Other antihypertensive medications: When used with other blood pressure-lowering drugs, there is an increased risk of hypotension (low blood pressure).
• Lithium: Lithium levels may increase in the blood when taken with Losartan, leading to potential toxicity.
• Potassium-sparing diuretics or potassium supplements: Taking potassium-sparing diuretics or potassium supplements alongside Losartan may increase the risk of hyperkalemia (high potassium levels).
• Non-steroidal anti-inflammatory drugs (NSAIDs): NSAIDs (e.g., ibuprofen, naproxen) may reduce the effectiveness of Losartan and may worsen kidney function.
• CYP3A4 inhibitors (e.g., ketoconazole, ritonavir): These may increase the plasma concentration of Amlodipine, increasing the risk of side effects such as swelling or dizziness.
• Diuretics: Patients using diuretics (e.g., furosemide) may be at increased risk of dehydration and electrolyte imbalance when taking BIOZART DUO.

Storage:

• Store Losartan + Amlodipine (AMLORA) 50mg/5mg Tablet at room temperature (between 15°C and 30°C), away from moisture, heat, and light.
• Keep out of reach of children.

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