About Cloxacillin (PHILCLOX) 500mg Capsule 100’s

Cloxacillin (PHILCLOX) 500mg Capsule is a semisynthetic penicillin antibiotic specifically formulated to combat infections caused by penicillinase-producing staphylococci. Unlike some penicillins, cloxacillin is resistant to degradation by beta-lactamase enzymes, making it particularly effective against certain strains of Staphylococcus aureus.

This broad-spectrum antibiotic is commonly prescribed for skin infections, respiratory tract infections, infections of the bones and joints (such as osteomyelitis), and infections following surgery or trauma. It works by inhibiting the synthesis of bacterial cell walls, ultimately leading to the destruction of the bacteria.

Indications of Cloxacillin (PHILCLOX) 500mg Capsule 100’s

Cloxacillin (PHILCLOX) 500mg Capsule is indicated for the treatment of:

• Respiratory tract infections (e.g., bronchitis, pneumonia)

• Skin and soft tissue infections (e.g., boils, abscesses, cellulitis)

• Bone and joint infections (e.g., osteomyelitis)

• Post-surgical and wound infections

• Septicemia and endocarditis caused by susceptible staphylococci

• Other infections caused by beta-lactamase-producing gram-positive organisms

Dosage and Administration of Cloxacillin (PHILCLOX) 500mg Capsule 100’s

Usual adult dose:

• 250 mg to 500 mg every 6 hours

• In severe infections, dosage may be increased based on clinical judgment

Pediatric dose:

• Based on body weight, typically 50 to 100 mg/kg/day divided into 4 doses

Administration guidelines:

• Best taken on an empty stomach, 1 hour before or 2 hours after meals

• Swallow capsule whole with water

• Continue full course as prescribed, even if symptoms improve early

Always consult a healthcare provider before initiating or adjusting dosage.

Side Effects of Cloxacillin (PHILCLOX) 500mg Capsule 100’s

Most side effects are mild and transient, including:

• Nausea

• Vomiting

• Diarrhea

• Stomach upset

• Skin rash or itching

Rare but serious side effects:

• Anaphylaxis (severe allergic reaction)

• Stevens-Johnson Syndrome

• Hepatitis or jaundice (especially with prolonged use)

• Clostridium difficile-associated diarrhea

Seek medical attention if severe allergic reactions or unusual symptoms occur.

Contraindications of Cloxacillin (PHILCLOX) 500mg Capsule 100’s

Cloxacillin (PHILCLOX) 500mg Capsule is contraindicated in patients with:

• Known hypersensitivity to cloxacillin, other penicillins, or beta-lactam antibiotics

• History of serious allergic reactions to cephalosporins or carbapenems (due to cross-reactivity)

• Severe renal or hepatic impairment without appropriate monitoring

Precautions for Cloxacillin (PHILCLOX) 500mg Capsule 100’s

• Use with caution in patients with renal or hepatic dysfunction

• Monitor liver function tests during prolonged therapy

• May interfere with certain laboratory tests (e.g., urine glucose tests)

• Prolonged use may lead to fungal or bacterial superinfections

• Ensure adherence to full course of treatment

Storage of Cloxacillin (PHILCLOX) 500mg Capsule 100’s

• Store in a cool, dry place at temperatures not exceeding 30°C

• Keep away from moisture and direct sunlight

• Store in original container

• Keep out of reach of children

• Do not use beyond the expiration date indicated on the packaging