About Cefixime (SITIFIX-400) 400mg Capsule 100’s

Cefixime (SITIFIX-400) 400mg Capsule 100’s is an oral antibiotic that belongs to the third-generation cephalosporin class. It is formulated for adult use and is particularly effective against a wide range of bacterial pathogens. This capsule is typically prescribed for conditions such as upper and lower respiratory tract infections, urinary tract infections, and uncomplicated gonorrhea. Due to its high bioavailability and long half-life, Cefixime allows for once-daily dosing in most cases, making it convenient for patients to adhere to their treatment regimens.

The active ingredient, cefixime, disrupts the formation of bacterial cell walls by binding to penicillin-binding proteins, ultimately leading to bacterial lysis and death. Its bactericidal action and resistance to degradation by most beta-lactamases make it an effective choice in treating infections caused by resistant organisms.

Cefixime (SITIFIX-400) is well-tolerated and commonly prescribed in both hospital and outpatient settings. It should be used under the supervision of a healthcare professional, especially in individuals with underlying health conditions or known allergies to beta-lactam antibiotics.

Indications of Cefixime (SITIFIX-400) 400mg Capsule 100’s

Cefixime (SITIFIX-400) 400mg Capsule 100’s is indicated for the treatment of infections caused by susceptible strains of microorganisms, including:

• Upper respiratory tract infections (pharyngitis, tonsillitis)

• Lower respiratory tract infections (acute bronchitis, chronic bronchitis exacerbations)

• Otitis media

• Urinary tract infections (cystitis, pyelonephritis)

• Gonorrhea (uncomplicated cervical/urethral infections)

• Typhoid fever and other gastrointestinal infections (off-label in some regions)

Dosage and Administration of Cefixime (SITIFIX-400) 400mg Capsule 100’s

• Adults and children over 12 years: One 400 mg capsule once daily or 200 mg every 12 hours, as prescribed.

• For gonorrhea: A single oral dose of 400 mg is typically effective.

• Can be taken with or without food; however, food may slightly delay absorption.

• Complete the full course of treatment, even if symptoms improve early.

• Dosage adjustments may be necessary for individuals with renal impairment.

Side Effects of Cefixime (SITIFIX-400) 400mg Capsule 100’s

Most side effects are mild and transient. These may include:

• Diarrhea

• Nausea

• Abdominal pain

• Dyspepsia

• Headache

• Dizziness

Less common but more serious side effects:

• Hypersensitivity reactions such as rash, itching, or hives

• Anaphylaxis (rare)

• Stevens-Johnson syndrome or toxic epidermal necrolysis (very rare)

• Blood disorders (e.g., thrombocytopenia, eosinophilia)

• Clostridium difficile-associated diarrhea

Contraindications of Cefixime (SITIFIX-400) 400mg Capsule 100’s

Cefixime (SITIFIX-400) 400mg Capsule 100’s is contraindicated in:

• Patients with known hypersensitivity to cefixime or other cephalosporins

• Individuals with a history of severe allergic reaction to penicillins or other beta-lactam antibiotics

• Patients with a history of antibiotic-associated colitis

Precautions for Cefixime (SITIFIX-400) 400mg Capsule 100’s

• Use cautiously in individuals with renal impairment; dosage adjustment may be needed.

• Monitor for signs of allergic reactions, especially in patients with a history of allergies.

• Prolonged use may result in superinfection or fungal overgrowth.

• Safety during pregnancy and lactation should be assessed by a physician.

• Do not use beyond the prescribed duration to reduce the risk of resistance development.

Storage of Cefixime (SITIFIX-400) 400mg Capsule 100’s

• Store at a temperature not exceeding 30°C in a dry place, away from direct sunlight.

• Keep the container tightly closed to protect from moisture.

• Keep out of reach of children.