About Fluconazole (DIFLU) 150mg Capsule 12’s

Fluconazole (DIFLU) 150mg Capsule 12’s is a broad-spectrum antifungal medication used to treat and prevent a variety of fungal and yeast infections. Each capsule contains 150mg of fluconazole, a triazole antifungal that works by inhibiting the synthesis of ergosterol, a key component of fungal cell membranes. This disruption weakens the fungal cell wall, ultimately leading to cell death. Fluconazole is known for its excellent oral bioavailability and ability to penetrate tissues and body fluids, making it effective in both localized and systemic infections.

Fluconazole (DIFLU) 150mg Capsule 12’s is commonly prescribed for infections caused by Candida species, including vaginal candidiasis (yeast infection), oropharyngeal and esophageal candidiasis, systemic candidiasis, and cryptococcal meningitis. It is also used as a preventive treatment for patients with compromised immune systems, such as those undergoing chemotherapy or living with HIV/AIDS. The single-dose regimen for uncomplicated vaginal infections offers convenient and effective treatment with high patient compliance.

Indications of Fluconazole (DIFLU) 150mg Capsule 12’s

• Treatment of vaginal candidiasis (yeast infections)

• Treatment of oropharyngeal and esophageal candidiasis

• Treatment of systemic candidiasis, including candidemia and disseminated candidiasis

• Treatment of cryptococcal meningitis, particularly in HIV-positive patients

• Prophylaxis of fungal infections in immunocompromised individuals (e.g., cancer, HIV)

• Treatment of dermatophyte infections, such as tinea corporis, tinea cruris, and tinea pedis

Dosage of Fluconazole (DIFLU) 150mg Capsule 12’s

• For vaginal candidiasis: A single 150mg oral dose (1 capsule).

• For oropharyngeal candidiasis: 200mg on the first day, then 100mg once daily for at least 2 weeks.

• For esophageal candidiasis: 200mg on the first day, then 100–200mg once daily for 2–3 weeks.

• For systemic infections: 400mg on the first day, followed by 200–400mg once daily.

• For cryptococcal meningitis: Initial dose of 400mg, followed by 200–400mg daily for at least 10–12 weeks.

• Prophylaxis in immunocompromised patients: 200–400mg daily depending on risk.

Always follow the dosage prescribed by your healthcare provider. Duration of treatment varies depending on the type and severity of infection.

Side Effects of Fluconazole (DIFLU) 150mg Capsule 12’s

Common side effects:

• Headache

• Nausea

• Abdominal pain

• Diarrhea

• Dizziness

• Skin rash

Less common or serious side effects:

• Elevated liver enzymes and liver toxicity

• Allergic reactions (e.g., swelling, hives, anaphylaxis)

• QT prolongation (heart rhythm changes)

• Severe skin reactions (e.g., Stevens-Johnson syndrome, toxic epidermal necrolysis)

• Seizures (rare)

Seek medical attention if you experience symptoms such as jaundice, dark urine, persistent nausea, or skin reactions.

Contraindications of Fluconazole (DIFLU) 150mg Capsule 12’s

• Known hypersensitivity to fluconazole or other azole antifungal agents

• Concurrent use with drugs such as cisapride, terfenadine (at high doses), pimozide, or quinidine, due to risk of serious heart rhythm disturbances

• Liver disease or renal impairment without medical supervision

• Use in pregnancy, especially during the first trimester, unless absolutely necessary

• Breastfeeding, unless advised by a healthcare professional

Precautions for Fluconazole (DIFLU) 150mg Capsule 12’s

• Use caution in patients with liver or kidney disease—monitor liver function tests and adjust dosing as needed.

• Monitor for signs of toxicity in patients on prolonged therapy.

• Caution is advised in patients with cardiac arrhythmias or risk of QT prolongation.

• May interact with warfarin, phenytoin, oral hypoglycemics, rifampin, cyclosporine, and other medications—consult your doctor for possible interactions.

• Use with caution in elderly patients and those with multiple comorbidities.

Storage of Fluconazole (DIFLU) 150mg Capsule 12’s

• Store in a cool, dry place below 30°C, away from direct sunlight and moisture.

• Keep in the original packaging until time of use.

• Keep out of reach of children and pets.

• Do not use beyond the expiration date printed on the label.